Translational Geroscience: Emphasizing function to achieve optimal longevity

Translational Geroscience: Emphasizing function to achieve optimal longevity

Among individuals, biological aging leads to cellular and organismal dysfunction and an increased risk of chronic degenerative diseases and disability. This sequence of events in combination with the projected increases in the number of older adults will result in a worldwide healthcare burden with dire consequences. Superimposed on this setting are the adults now reaching traditional retiremen...

Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity.

Most nations of the world are undergoing rapid and dramatic population ageing, which presents great socio-economic challenges, as well as opportunities, for individuals, families, governments and societies. The prevailing biomedical strategy for reducing the healthcare impact of population ageing has been 'compression of morbidity' and, more recently, to increase healthspan, both of which seek ...

Introducing Adaptivity to Achieve Longevity for Software

Long living software systems (LLSSs) must provide the flexibility to react to changes in their operating environment as well as to changes in the user’s requirements, even during operation. Self-adaptive software systems (SASSs) face adaptivity at runtime within predefined bounds. Yet, not all types of necessary variations can be anticipated and unforeseen changes to software may happen. Thus, ...

Calorie Restriction, Longevity and Cognitive Function

Geroscience: Linking Aging to Chronic Disease

Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches. Given that the elderly population is dramatically increasing and that aging is the greatest risk factor for a majority of chronic diseases driving both morbidity and mortality, it is critical to expand geroscience research directed at extending human healthspan.